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informs about the latest news in gene expression profiling using qPCR
and related methods, which are compiled and summarised on www.Gene-Quantification.info
Advanced Molecular Diagnostics for Biomarker Discovery
I have the honour to present the first special issue in ‘Biomolecular Detection and Quantification’ (BDQ) which is entitled ‘Advanced Molecular Diagnostics for Biomarker Discovery’. It is published in conjunction with the last qPCR and NGS 2015 event which took place in March 2015 in Freising Weihenstephan, Germany (www.qPCR-NGS-2015.net) covering the same theme. This aim of this special issue is to present the newest developments in highly sophisticated molecular techniques and related scientific applications in combination with the latest data analysis tools. Furthermore, the implementation of these advanced molecular diagnostics tools for discovery, quantification and validation of molecular biomarkers will be presented. Since 2004 the history of this conference series was primarily focused on quantitative PCR (qPCR) related techniques and applications, but since 2010 the focus was broadened to digital PCR (dPCR), next generation sequencing (NGS) and the underlying complex data analysis applying bioinformatical tools. This history is nicely summarized by the BDQ editors in one of the previous editorials ‘qPCR, dPCR, NGS – A journey’.
have immense scientific and potential clinical value in the diagnostic
testing pipeline. They span the broad diagnostic sector from the genome
to the phenome over various ‘-ome’ levels and have been used since the
earliest days of the application of molecular biology. A biomarker
signature is capable of revealing specific biological traits or
measurable physiological changes, according to a disease status,
physiological or pathological condition, or after drug application. As
novel gene-based diagnostics proliferate, they will be increasingly
important to drug development, approval and later in clinical practice.
There are numerous promising singular biomarkers or more complex
multiple biomarker signatures available, the most important of which
are currently used for assessing drug development, patient
stratification or measuring the efficacy of treatment in therapeutic
medicine. Clearly there is a translation problem to transfer the
results from molecular diagnostics research to drug development and
finally clinical practice. In future, biomarkers and their interaction
on various ‘-ome’ levels will increase the molecular and cellular
knowledge of disease and drug mechanisms. ... ... ...
Issue: Advanced Molecular Diagnostics for Biomarker
Discovery – Part I
editor's introduction for BDQ special issue: ‘Advanced Molecular
Diagnostics for Biomarker Discovery’
of post-mortem and physical degradation on RNA integrity and quality.
of between-run variation in a multi-plate qPCR experiment.
potential of circulating extracellular small RNAs (smexRNA) in
veterinary diagnostics—Identifying biomarker signatures by multivariate
of a workflow for the molecular characterization of single cells by
next generation sequencing.
for stochastic sampling variation and qualitative sequencing error in
next generation sequencing.
in PCR troubleshooting: Expect the unexpected?
amplicons (ΔAmp)—a new molecular method to assess RNA integrity.
of bias associated with high-multiplex, target-specific
resequencing and variant validation using pxlence PCR assays.
and detection of beak and feather disease virus in psittacine birds in
Aims and Topics: Today, one of the biggest challenges for biologists is the ability to understand and analyze the genome expressed in a given cell type in the tissue environment, which means you can specifically isolate these cells and work on very small quantities of biological material. The aim of the congress is to bring together internationally renowned experts in the field and offer an overview of the present knowledge for obtaining high quality molecules and future developments in "omic" tools (DNA, RNA and protein) for genome analysis and its expression at the cell level. The latest advances in technology in the field will be introduced (flow cytometry, laser capture microdissection, NGS, digital PCR, WGA, LC-MS/MS, RPLA, etc).
The symposium will be divided into four sessions introduced by keynote lecturers, experts in their field :
1- Sampling methods (flow
cytometry, laser capture microdissection, DEP array)
The comprehensive meeting will
focus on new developments in qPCR technology, concentrating on
improvements to qPCR design, the acquisition of accurate data, and
efficient data analysis. Particular emphasis will also be given to the
use of qPCR in Cancer diagnosis and the use of dPCR in the clinic,
covering applications such as infectious disease diagnostics and cancer
Attending this meeting will
provide you with an excellent opportunity for networking with the
world’s leading experts, helping you to find unique solutions and build
long term collaborations.
Welcome to Exosomes and Liquid Biopsies Asia 2016. This conference is being held in one of the hubs of trade and commerce in Asia -- Taipei, Taiwan. Just a short flight from most business destinations in Asia and a nonstop flight from the United States and Europe, Taipei is an excellent meeting place and venue to bring together academics and industry participants from Asia, Europe and the United States to focus on an exciting area of research: Liquid (biofluid) biopsy development driven by circulating biomarkers such as circulating nucleic acids, circulating extracellular vesicles (such as exosomes) and circulating tumor cells (CTCs).
This conference brings together key opinion leaders, established researchers as well as junior investigators for oral presentations, poster presentations as well as an exhibition to bring to the researchers the most up-to-date technologies and products from companies to accelerate their research.
Academics from across Asia, Europe and the United States as well as Industry Participants from companies large and small would find this two-day conference extremely valuable as a learning and networking experience.
Biomarker Classes: Exosomes, Microvesicles, Circulating-Free DNA
(cfDNA), Circulating RNA, Circulating Tumor Cells (CTCs)
21st World Congress on Advances in Oncology
& 19th International Symposium on Molecular Medicine
The continued interest and
increasing support that our annual Congress on Advances in Oncology and
Symposium of Molecular Medicine has gained over the years, motivates us
to repeat this success this year in October 2016. Over the last 20
years we have consistently welcomed a broad international audience,
which surpassed 500 participants in 2015.
Detection and Quantification" -- Call for Papers
Biomolecular Detection and Quantification (BDQ) is an open access, peer-reviewed international journal dedicated to championing excellence in molecular study design, measurement, data analysis and reporting. Its focus is on the application of qualitative and quantitative molecular methodologies to all areas of clinical and life sciences. Download the recent BDQ papers on Elsevier Science Direct.
The journal has two main aims:
We look forward to receiving your paper!
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